Award-Winning Clinical Excellence
Our latest randomized controlled trial, published in The Spine Journal, was honored with the prestigious “Abstract of the Year” and selected for a Plenary Presentation. This recognition underscores our commitment to setting new standards in minimally invasive spine care.
Alexis Kelekis, MDᵃ, Giuseppe Bonaldi, MDᵇ, Alessandro Cianfoni, MDᶜ,ᵈ, Dimitrios Filippiadis, MDᵃ, Pietro Scarone, MDᶜ,ᵈ, Claudio Bernucci, MDᵇ, David M. Hooper, PhDᵉ, Hadas Benhabib, MDᶠ, Kieran Murphy, MDᶠ,*, Josip Buric, MDᵍ
Institutional Affiliations:ᵃ University General Hospital Attikon, Athens, Haidari 12462, Greece
ᵇ Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Lombardia 24127, Italy
ᶜ Department of Neuroradiology, Neurocenter of Southern Switzerland, Lugano 6900, Switzerland
ᵈ Department of Interventional and Diagnostic Neuroradiology, Inselspital University Hospital of Bern, Bern 3008, Switzerland
ᵉ Spinafx Medical, Vaughan, Ontario, Canada
ᶠ Toronto Western Hospital, University Health Network, Toronto, Canada
ᵍ Casa di Cura San Camillo, Forte dei Marmi, Lucca 55042, Italy
Collected Literature
Explore our curated collection of peer-reviewed studies, clinical data, and medical literature supporting the efficacy of oxygen-ozone therapy in spinal care.
1,750 Patients Show Intradiscal Oxygen-Ozone 80%/75% Effective at 6mo/18mo
80% success rate and 20% failure rate in 1750 patients followed up to 6 months. Success dropped to 75% and...
Intradiscal Oxygen-Ozone Superior to ESI Injections at 12 Months
Prospective, double blind, RCT; Ozone + ESI vs ESI alone.
Intradiscal Oxygen-Ozone 82%/88% effective over 5/10 years
75% of patients were able to avoid surgery, and of the patients that avoided surgery, 82% improved at 5 years,...
8,000 patient Meta Analysis: 62.5-86% effective, 0.6% adverse event rate
62.5-85% in terms of leg pain relief. The likelihood of showing improvement on the modified MacNab scale was 79.7%.
2,597 patient Systematic Review – Intradiscal Oxygen-Ozone Safe and Effective
9 superior, 3 equivalent to control, 3 not assessed.
Intradiscal Oxygen-Ozone Non-Inferior to Microdiscectomy at 6 Months
71% of patients avoided surgery. Non-inferior to microdiscectomy surgery.
Whitepaper
Filling the Therapeutic Gap in Herniated Disc Treatment: Inconsistencies in Diagnosis and Treatment Between Failed Conservative Care and Surgery.
Back pain is the #1 source of workdays lost to disability globally[1], with approximately 80% of adults experiencing a herniated disc in their lifetime[2] and an estimated prevalence of symptomatic herniated discs of 1-3% of patients[3]. The pain, loss of productivity, and related mental health deterioration resulting from chronic pain
