Citation: Steppan J, Meaders T, Muto M, Murphy KJ. A metaanalysis of the effectiveness and safety of ozone treatments for herniated lumbar discs. J Vasc Interv Radiol. 2010 Apr;21(4):534-48. doi: 10.1016/j.jvir.2009.12.393. Epub 2010 Feb 25. PMID: 20188591.
Design: Meta-analysis
Patients: 8000
Effectiveness: 62.5-85% in terms of leg pain relief. The likelihood of showing improvement on the modified MacNab scale was 79.7%.
Safety: 0.6% adverse event rate
Author Comment: Oxygen/ozone treatment of herniated discs is an effective and extremely safe procedure.