Citation: Sconza C, Leonardi G, Kon E, Respizzi S, Massazza G, Marcacci M, Di Matteo B. Oxygen-ozone therapy for the treatment of low back pain: a systematic review of randomized controlled trials. Eur Rev Med Pharmacol Sci. 2021 Oct;25(19):6034-6046. doi: 10.26355/eurrev_202110_26881. PMID: 34661263.
Design: Systematic review of ozone-oxygen therapy (OOT) RCTs for low back pain.
Patients: 2597
Effectiveness: 9 superior, 3 equivalent to control, 3 not assessed.
Safety: No reported adverse events.
Author Comment: OOT has proven to be a safe treatment with beneficial effects in pain control and functional recovery at short to medium term follow-up