Citation: Kelekis A, Bonaldi G, Cianfoni A, Filippiadis D, Scarone P, Bernucci C, Hooper DM, Benhabib H, Murphy K, Buric J. Intradiscal oxygen-ozone chemonucleolysis versus microdiscectomy for lumbar disc herniation radiculopathy: a non-inferiority randomized control trial. Spine J. 2022 Jun;22(6):895-909. doi: 10.1016/j.spinee.2021.11.017. Epub 2021 Dec 9. PMID: 34896609.
Patients: 49
Design: RCT, single blinded, assessor-blinded, non-inferiority trial.
Effectiveness: 71% of patients avoided surgery. Non-inferior to microdiscectomy surgery.
Safety: No reported adverse events.
Author Comment: Intradiscal oxygen-ozone … met the non-inferiority criteria to microdiscectomy on 6-month mean leg pain improvement. Both groups achieved rapid significant clinical improvements that persisted. 71% undergoing intradiscal oxygen-ozone were able to avoid surgery.